Fashion business management Essay Example | Topics and Well Written Essays - 1500 words

Design business the board - Essay Example Attributable to the perplexing dynamisms of the style business, numerous financial specialists have avoided this speculation, considering it as a high hazard adventure, which is just given thought by organizations at later phases of their turn of events and development, while without a doubt, not very many, most transcendently individual-based endeavors, are occupied with the design business as new companies (Giacobello, 2000 p44). To this end, it turns out to be fundamentally basic for any individual intrigued by the design business to subscribe to seeing all the elements related with the business, before any commitment, either as financial specialists or chiefs of style organizations. Along these lines, this conversation tries to break down design business the executives, with the end goal of building up the sourcing techniques, just as the social contemplations that requires to be made, for the style organizations that try to work inside the worldwide commercial center. The cardinal guideline for any business has consistently been to know the client (Blaszczyk, 2008 p23). This standard serves to direct business in the way of activities, necessitating that the sole explanation behind which a business is built up is to serve its clients, through understanding their needs and fulfilling them. Accordingly, for a style business, the sourcing methodologies are pegged on the necessities of the clients, which has to do with the quality that the clients are keen on, the scope of costs they can manage the cost of and ready to pay for the design items, just as the time inside which the clients should be provided with the items (Gale and Kaur, 2004 p18). In this way, to satisfy the above client prerequisites, a style business merchandiser require applying the accompanying systems: The design business is portrayed by request changes, where a particular sort or style of attire or garments could be profoundly requested in a specific season, and later the interest for similar goes to be low (Han, 2003 p33). Accordingly, attributable to the

Anthropology Essay Example | Topics and Well Written Essays - 250 words - 12

Human studies - Essay Example The working class had the option to help the development of the urban communities. All things considered, industrialization is a necessary essential for guaranteeing the development of Mega Urban Region (MUR). At the point when we think about the pace of development of the urban communities, it becomes obvious that Shanghai and Ho Chi Minh City encountered the most elevated development rates, which don't appear to decrease later on. The examination of the two urban areas uncovers that they have an exceptionally powerful inward zone. The zone encountered the most elevated development rate as far as business openings and populace. The dynamism and improvement of the internal zone become driven by both the de-clog procedure of the urban private and creation capacities exuding from the center of the urban areas. Thusly, the inward zones have a higher possibility for progression, which may imply that the Shanghai MUR may proceed with its development. While empowering the development of the Mega Urban Regions, I accept that the individuals ought to move organizations and individuals out of the center. Such a move will likewise support the advancement of the rustic territories in the outskirts of the urban areas, prompting further

The Comedy of Tradgedy Essay -- Literary Analysis, Charlie Chaplin

Viewed by grandparents, known by guardians, yet rapidly brief in the psyches of youthful ones, Charlie Chaplin is the first â€Å"tramp.† From movies, for example, The Kid or The Circus, Chaplin is the substance of quiet movies. His one of a kind blend of satire and disaster is a cutting edge reconstruction of Shakespeare’s style. Many would concur that Charlie Chaplin is the Shakespeare of quiet movies. From clothes to newfound wealth to banish, Chaplin is an immortal comic and will consistently be recognized as the â€Å"tramp.† People take a gander at a well known figure like Chaplin and envision a captivating existence with everything available to them, yet the exact opposite thing individuals would envision is a youth loaded with affliction and neediness. As per Alan Schroeder, noted biographer, Chaplin was destined to a boozer father and an intellectually crazy mother (22-24). April 16, 1889, the very first moment of the best on-screen characters of the fil m age was conceived. Charlie Sr. what's more, Hannah Chaplin named him after his vaudevillian father (Schroeder 21). Charlie Sr. was probably the best vaudevillian in England at that point, until his lips contacted liquor (Schroeder 22). Charlie's dad turned into an intolerable alcoholic that wound up leaving Hannah and their two children, Charlie and Sidney, to battle for themselves (Schroeder 22). The pressure this left on Hannah was poisonous. Hannah attempted to accommodate the kids by filling in as a needle worker for the congregation (Schroeder 22). Before she had Charlie she too was a vaudevillian, however after Charlie's introduction to the world she had surrendered it (Schroeder 22). Indeed, until she could scarcely manage the cost of nourishment. She endeavored to return to a phase vocation, yet work was rare and tedious (Schroeder 22). Sidney and Charlie were carrying on with a real existence no youngster ought to need to persevere. Inside a couple of years, Hannah had br ought forth two chil... ...lways be somebody who might be listening that adores him.Van Gogh, Picasso, and Chaplin will consistently share two things for all intents and purpose: their creative capacities, and their absence of thankfulness until they were no more. For Picasso and Van Gogh gone implied passing, yet for Chaplin gone implied oust. After Chaplin's drawn out outcast for his socialism standards, he indeed came back to the U.S. after the Second Red Scare had faded away (Encyclopedia of World Biography 439). Upon his arrival, Chaplin was reached about accepting foundation grants (Authors and Artists for Young Adults Par.2) 4 Academy Awards and 4 Academy Award designations were just piece of the numerous acknowledgments he got (Authors and Artists for Young Adults Par.2). At long last Chaplin had gotten the honors he merited. Chaplin was a man who contributed such a great amount to the film business just as a huge number of chuckles his movies incited.

Essay Writing Tip: How to Write a Strictly Argumentative Statement For Argumentative Essay

Essay Writing Tip: How to Write a Strictly Argumentative Statement For Argumentative EssayYour thesis statement for an argumentative essay is very important. If you have never written a thesis before, this is a great way to get started. After all, it's not easy writing a thesis statement for an argumentative essay. Here are some tips that can help you in making your thesis statement for an argumentative essay.If you are learning how to write a thesis, start with a blank sheet of paper and make a mark at the bottom of the page for each line of your paper. Then, create a new line at the bottom of the page for each point that you want to make. As you learn how to write a thesis, you'll want to put the notes on the line that goes from line one to line three.If you're worried about the rules for grammar, then you can look up the syntax for sentence structure. A few years ago, syntax wasn't a big deal, but now they are always using them to get rid of a situation.When you are writing an arg umentative essay, think about the kind of language that your audience will use. Try to make your thesis statement for argumentative essay have very different things in the thesis statements for argumentative essay. Most students have been raised on reading, writing, and speaking. You can learn a lot about the argumentative essay by reading.To use this technique in your thesis statement for argumentative essay, make a list of the arguments that you want to make and a list of the reasons that you believe the argument is true. Use this list as a basis for making your thesis statement for an argumentative essay.Write your conclusion in the last paragraph. It doesn't have to be long, but it should be powerful and convincing. Avoid giving your reader too much information at the end of your thesis statement for an argumentative essay.The conclusion must make your argument very clear and concise. You don't want your conclusion to be too long, because it can become a 'wasted space.' Do your best to follow the thesis statement for argumentative essay format, and you'll be on your way to writing an impressive thesis statement for an argumentative essay.

The Renaissance Period - 1455 Words

The Renaissance period, also known as the time of â€Å"rebirth†, brought many new ideas from the early 14th to late 16th century. These ideas derived from old medieval beliefs coinciding with new modernist attitudes (â€Å"Basic Ideas of the Renaissance,† 2012). Of the many changes that occurred, politics and power, humanism, and the Protestant Reformation predominated. Many desired a strong central government and an end to feudalism, which gave way for the establishment of monarchies (â€Å"Introduction to Renaissance,† n.d.). The humanist movement gave individuals a different perspective in regards to life satisfaction and limits of reason (Nauret, 1995). With that being said, to recognize man fully, an emphasis was placed on art, activities, and education of the Classical World (â€Å"Basic Ideas of the Renaissance,† 2012). With the establishment of monarchies and humanism, the Renaissance period brought to light the issues of the Church and Catholicis m. The movement that appeared from this conflict is known as the Protestant Reformation. Martin Luther, a major supporter of the Protestant Reformation, brought forth a different way of thinking and perspective that reflected traditional Christian ideas (Fiero, 2011). Much of the arts in the Renaissance period emulated the ideals and struggles of this time. One popular play known worldwide is Hamlet written by William Shakespeare, who is known as the greatest English playwright of all time (Fiero, 2011). The character Hamlet displayed manyShow MoreRelatedThe Renaissance, Renaissance And The Renaissance Period775 Words   |  4 Pages Renaissance is a time period that starts a transitional cultural movement in Europe between medieval times and modern times. It means rebirth and begins in 14th century and lasts into the 17th century. Through out this time, many aspects were influenced by this cultural movement, such as art, music, science, religion and politics. Renaissance wa s marked by the humanistic revival, and people in Europe used this method in study, in order to searched for realism and human themselves in art.Read MoreThe Period Of The Renaissance Period887 Words   |  4 PagesRenaissance literally means rebirth. It refers particularly to the rebirth of learning during this period. There was a tremendous revival of classical literature and art, but in the end it was the joining of this with the intellect of the Italian people that lead to the change of the Western World. This period was definitely more than just a rebirth though, it was also an age of new discoveries, both geographic and intellectual. Both of these resulted in changes of tremendous importance for WesternRead MoreThe Renaissance Period1577 Words   |  7 PagesThe Renaissance The Renaissance period was between 1400-1600 century. It began in Italy and spread to the rest of Europe. The Renaissance time is were self paintings mostly came from. In most of the painting the people were nude. They started making the painting 3D. There are many things about the Renaissance. Renaissance means born a new. The concept enshrined in the world of Renaissance is actually one of rebirth. It was considered the beginning of modern history. The High Renaissance was fromRead MoreThe Renaissance Period1592 Words   |  7 PagesThe Renaissance Sides 1 The Renaissance period was between 1400-1600 century. It began in Italy and spread to the rest of Europe. The Renaissance time is were self paintings mostly came from. In most of the painting the people were nude. They started making the painting 3D. There are many things about the Renaissance. Renaissance means born a new. The concept enshrined in the world of Renaissance is actually one of rebirth. It was considered the beginning of modern history. The High RenaissanceRead MoreThe Period Of The Renaissance1449 Words   |  6 PagesThe Renaissance, â€Å"rebirth,† began in the fourteenth century which spanned all the way to the sixteenth century. This great cultural transition that spread throughout Europe was one of the most important periods of European history as the ideas of the Medieval age shifted to a more modern age. Throughout this period Europe experience many major achievements in literature, architecture, philosophy, and of course art. Out of the Renaissance, E urope gained many historically important artists like LeonardoRead MoreThe Renaissance Period836 Words   |  4 PagesThe Renaissance Period The term Renaissance comes from the French word rebirth. The Renaissance was a period of European history, considered by modern scholars that occurred between 1300 and 1600. Many dramatic changes happened during the Renaissance. The Renaissance was a period of new inventions and beliefs. This period of time was drastically different from the Middle Ages. During the Middle Ages the church had most of the power and its economy was based primarily on agriculture. ExplorationRead MoreThe Renaissance Period3406 Words   |  14 PagesThe argument being put forward in this dissertation is that the Renaissance in Europe, with specific emphasis on Italy, during the 15th Century, was the most influential period in developing the ‘early modern’ human society. Many believe that this was due to its almost perfect location between Western Europe and the Eastern shore of the Mediterranean. By analysing various factors and sources, as well as different aspects of society, for example political factors and the views of contemporary textsRead MoreThe Renaissance Period1254 Words   |  6 PagesThe Renaissance started in Italy during the 1300’s before spreading throughout Europe in the 1500 and 1600’s. It came about because of a change in the way of thinking. In an effort to learn, people began to want to understand the world around them. This study of the world and how it works was the start of a new age of science. â€Å"The people were curious and questioned the known wisdom of the church. They began to use experimentation and observation to solve worldly problems†. (Johnson). ManyRead MoreRenaissance Art : The Renaissance Period867 Words   |  4 PagesRenaissance Art The Renaissance time period was home to many new ideas in art. This includes new artists bringing forth ideas that had yet to be discovered and made popular. New themes and types of art were also being brought forward during this period. Numerous artists had to of been present to make Renaissance art the way it is. Some of the world’s most famous artists were working during this time period, including Leonardo da Vinci, and other artists like Sandro Botticelli and Lorenzo GhibertiRead MoreThe Baroque And The Renaissance Period947 Words   |  4 PagesThe Art period went through many different transitional phases to become what it is now, but the most famous of these phases are the Baroque and the Renaissance period. During the Renaissance saw the appearance of the â€Å"rebirth† of its country. the painters use realistic portrayals of nature and the human figure by artists that were inspired by the ancient Greek and Roman art and culture. However, during the Baroque creative phase,the artwork that seemed to be unrealistic, clear and produced many

Transitional Housing For Incarcerated Addicts Analysis

Transitional Housing for Incarcerated Addicts Returning to the Community As previously noted, my final project is an intervention/2nd tier prevention effort to reduce both recidivism and relapse in the forensic substance abuse population. I currently live in Mercer County, Pennsylvania, which is a rural county that has extremely limited resources. Within the whole county, there is not a single inpatient residential drug and alcohol treatment facility, and only 2 licensed drug and alcohol outpatient treatment centers, as well as 2 methadone clinics. While treatment is highly important, my intervention plan focuses on the crucial time post-release from prison and/or treatment, where vulnerability is most high for relapse and recidivism.†¦show more content†¦Residential Treatment Facilities contracted with the Single County Authority (Gaudenzia – Erie, PA; Turning Point – Franklin, PA; White Deer Run – Allenwood, PA; Pyramid – Altoona, PA; Alpine Spr ings – Linesville, PA; Gateway – Aliquippa, PA; Greenbriar – Washington, PA; Conewago – Pottsville, PA) – As many individuals leaving either jail to go to an inpatient facility, or leaving the community to go directly to treatment facility are uninsured, they are funded through the Single County Authority and sent to facilities who have direct contracts. Since Pennsylvania is cracking down on treatment outcomes and success rates, they would have a vested interest in improved success rates post-discharge from their facilities. Dialogue, communication, and outreach can occur with these facilities to explain the purpose of the transitional living facility and provide information to obtain referrals. Mercer County Behavioral Health Commission (Single County Authority) – As my current employer, the Mercer County Behavioral Health Commission not only provides assessments to incarcerated individuals to send them to treatment, they also provide case management services related to non-treatment needs. These case management services would be essential to help individuals within the housing facility obtain needed resources, including health insurance, monitoringShow MoreRelatedConsequences Of A Criminal Record2687 Words   |  11 Pagescriminal record is much more severe than one might perceive, and it doesn’t discriminate to either gender. The real consideration is the life after imprisonment, and the issues and challenges the individual is faced with. Associated with each economic analysis approach is the discussion on the consequence of a criminal record. Former inmates are faced with barriers that put limitations to their social status when attempting to re-integrate back into society. With recognition and traction of the criminalRead MoreCritical Analysis of Women Behind Bars Essay4460 Words   |  18 Pagescritical analysis of the book, â€Å"Women Behind Bars: The Crisis of Women in the U.S. Prison System. This p aper will Introduction Journalist Silja Talvi’s Women Behind Bars: The Crisis of Women in The U.S Prison System is an overview of issues affecting incarcerated women. The goal of the book Women Behind Bars is to increase the awareness about the growing population of women prisoners. Women Behind Bars presents a number of important issues regarding women prisoners. Incarcerated women’s storiesRead MorePrison Reform Topic Paper : Prisons6604 Words   |  27 Pages2006). Since the mid-1970s, the United States has engaged in a race to incarcerate that has resulted in a prison population expanded to a level previously unknown in any democratic society (Burt, 2010). The US has over 2 million of its citizens incarcerated, which accounts for 25% of the world s imprisoned population (Forman, 2011). The system has grown seven fold since the 70 s and continues to expand steadily every year (Forman, 2011; Colgan, 2006). (T)here are various types and divisions of

Amphiphilic Based Lipid Nanocarriers in Drug Delivery System

Question: Discuss about theAmphiphilic Based Lipid Nanocarriers in Drug Delivery System. Answer: Background and Long-Term Objectives Poor penetration of the drugs with various compositions across the BBB (blood-brain barrier) is evident in the biomedical research. This impacted greatly the pharmaceutical interventions of various neurodegenerative disorders, brain tumours and impairment of the central nervous system (Gan et al., 2013). BBB is the main route for the therapeutic compounds targeted to the brain. But, majority of the neuro medicines, transporter ligands and hydrophilic molecules have less permeability across this region. Nanocarriers, especially amphiphilic based lipid nanocarriers provide unlimited therapeutic potential (Nicolas et al., 2013). Hence, this research would design and test the effectiveness of biodegradable nanocarriers that can carry both hydrophobic and hydrophilic drug components. Various drug delivery approaches have been designed in order to overcome BBB, for instance: modification of BBB functions, circumvention of BBB and modification of drug molecules. Invasive strategies used for drug delivery like intracerebral or intraventricular drug administration are highly effective in avoiding BBB. But, these processes also include certain limitations like infection risks (Kumari, Yadav Yadav, 2010). In case of non-invasive strategies such as drug administration via nasal pathway is also effective but limited distribution and low amount of drug delivery are the identified two major drawbacks (Yavlovich et al., 2010). In the present era, different nanotechnology platforms in medial biology field have obtained remarkable attention including both therapies and diagnostics. Innovatively designed multifunctional nanoparticles as drug carriers have impelled exponential development in medicinal application. The designs include liposomes, antibody-drug conjugates, dendrimers, and so on, which are based on exceptional assemblies of biological, natural or synthetic components. Mechanisms There are various types of targeting mechanisms demonstrated by the nanocarriers, like: active targeting, passive targeting, temperature specificity and pH specificity. Passive targeting is said to be the process where the nanocarriers travel down to a targeted system, suppose a tumour vascular system, become entrapped and accumulate within the target cells (Mura, Nicolas, Couvreur, 2013). The accumulation happens due to increased retention effect and permeability. Active targeting includes incorporation of target molecules like antibodies or ligands on the nanocarrierss surface, which are particular to certain cells of the system. Nanocarriers have higher ratio of surface area to volume that allow various ligands to attach to the surfaces (Nicolas et al., 2013). The targeting molecules allow the nanocarriers to penetrate directly across the cells. Certain nanocarriers only release drugs, which have specific pH ranges. The specificity of pH allows the nanocarriers to release drugs d irectly into the target site. Nanocarriers, which only liberate drugs at particular pH could therefore be applied to further release drugs in acidic environment. Some nanocarriers deliver drugs at particular temperature. It is evident that temperature of the tumour cells are higher (almost 40c) comparative to the rest of the system, which further enable to safeguard drug delivery at tumour-specific site. Recent Progresses and Specific Hypotheses Efflux pumps and interendothelial tight junctions are recognized as major limiting functions of the BBB that restrict drug penetration to the brain (Li et al., 2011). Hence, functional modification of the BBB is presently investigated. Drug penetration testing was done under strict ethical consideration that used cell culture model. Niosomes from the non-ionic surfactants have been designed that present amino acids, glucose analogues and BBB carrier ligands within the surfaces. Tissue distribution of the niosomes was assessed by using an in-vivo imaging system. The tissue was stained with Evans blue, an azo dye. Hypothesis: The amphiphilic based lipid nanocarriers are effective in drug delivery across the BBB by targeting the brain. Short-Term Goal of this Research Study: To alter the physio-chemical properties of the drug delivery molecules by increasing cationic charge or lipid solubility Maximization of lipid solubility could improve transport of a drug across BBB. This in turn could increase the uptake by the peripheral tissues. Further, sequestration within the capillary bed causes reduced concentration within the blood and the CNS. Non-ionic surfactant depended nanocarriers could demonstrate a versatile system. The size of the nanocarriers could be approximately between 50-200nm that have the capacity to entrap comparatively large amount of lipophilic and hydrophilic therapeutic agents. Such amphiphilic based lipid nanocarriers could protect encapsulated drugs from the gastrointestinal breakdown. These nanocarriers could be targeted in the brain by the surface alteration with the ligands for receptor proteins or BBB transporter. Nanocarriers that target the BBB receptors and physiological transporters can cross the endothelial cell layers of the brain. Long-Term Goals: Objective 1: To understand the mechanism of BBB (year 1 to 2) Transient rise of the permeability of BBB pathways and modifying efflux pump could improve drug delivery. Side-effects, safety and reversibility would be monitored continuously. BBB itself could act as the CNS drug source. If BBB becomes leaky, it allows immune cells entry to the CNS. Nevertheless, the immune cell passage across BBB is regulated and leakage acts as byproduct of the immune cells trafficking. The luminal surface does not necessitate passage across BBB and thereby, targeting peripheral tissues are highly effective to almost half of BBB. The luminal receptors, which stimulate endothelial cells of the brain are readily targetable. Objective 2: To understand uptake and diffusion of various nanocarriers along with ligand-receptor combinations across BBB (year 1 to 2) It is seen that intravenously administered niosomes that contain glucose analogue provide high fluorescent signals as a ligand within the brain tissue (Mura, Nicolas, Couvreur, 2013). This could be compared and checked in living mice model by incorporating non-targeted niosomes. Simultaneously, other forms of targeted nanocarriers like polymeric nanoparticles or liposomes could also be checked by using cell culture models of BBB. These nanocarriers would contain therapeutic drugs for instance curcumin as a load and would be introduced to various ligands, which would be attached to the surface in order to target receptors or BBB transporters. Impact of Proposed Research The incorporation of medicine and nanotechnology has given rise to major advancements, which have further improved medication administration of various diseases. The application of amphiphilic based lipid nanocarriers would improve delivery of drug to the brain by smoothly crossing the BBB. As medicinal transformation is becoming more advanced, utilization of amphiphilic based lipid nanocarriers would change and invalidate conventional treatment criteria. However, the researchers should be careful enough about reversibility, safety and side-effects of the innovative applications. References Gan, L., Wang, J., Jiang, M., Bartlett, H., Ouyang, D., Eperjesi, F., Gan, Y. (2013). Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers.Drug discovery today,18(5), 290-297. Kumari, A., Yadav, S. K., Yadav, S. C. (2010). Biodegradable polymeric nanoparticles based drug delivery systems.Colloids and Surfaces B: Biointerfaces,75(1), 1-18. Li, X., Qian, Y., Liu, T., Hu, X., Zhang, G., You, Y., Liu, S. (2011). Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.Biomaterials,32(27), 6595-6605. Mura, S., Nicolas, J., Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery.Nature materials,12(11), 991-1003. Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., Couvreur, P. (2013). Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery.Chemical Society Reviews,42(3), 1147-1235. Yavlovich, A., Smith, B., Gupta, K., Blumenthal, R., Puri, A. (2010). Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications.Molecular membrane biology,27(7), 364-381.